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KMID : 0386520140220020067
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Research Institute of Korean Medicone
2014 Volume.22 No. 2 p.67 ~ p.79
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Experimental Research of Baecksunpijibujabokhap-banng(BJBB) on Atopic Dermatitis Treatment
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Sim Boo-Yong
Ji Joong-Gu
Lee Won-Yung
Kim Su-Jung
Kim Hyo-Young
Lee Ji-Young
Kim Dong-Hee
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Abstract
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In order to investigate the efficacy of BJBB on atopic dermatitis, various immune related factors were studied. The results and conclusions are as follows. Atopic dermatitis symptoms were improved in BJBB treated group and significant decrease in dermatitis index were observed in 13 weeks. ALT, AST and BUN, Cr levels were all with in the normal ranges in BJBB treated group, indicating no induced toxicity. BJBB treated group showed significant decrease in CD4+, CD11b+/Gr-1+ immune cell ratio in dorsal skin by 33% and 62% respectively. BJBB treated group showed significant decrease in the expression of IL-4, IL-5, IL-13 and histamine by 83%, 62%, 53% and 61% respectively. Also the group showed decrease in the transcription of IL-4, IL-5 and IL-13 mRNA in spleen by 41%, 52% and 50% respectively. BJBB treated group showed decrease in the expression of IgE by 57% respectively. The results above indicated that treatment of BJBB improved atopic dermatitis symptoms by immune modulation activity a clinical evidence. thus, BJBB has a potential use as a composition of medicinal plants for treatment against inflammation related disease.
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KEYWORD
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Baecksunpijibujabokhap-banng(BJBB) , atopic dermatitis , immune cell , cytokinin , mRNA
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